The OPP says the plane took off about 5:30 p.m. yesterday afternoon en route to a tourist camp north of the community.
Police say the plane went down soon after takeoff about 200
metres from shore in the Bruce Channel between Cochenour and
McKenzie Island.
A man and woman from the United States are believed to have been the only people on board but their identities have yet to be confirmed.
There is no word on what caused the crash, although it was cloudy and windy and the lake was choppy at the time.
The Transportation Safety Board is also sending two investigators to the accident scene.