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The OPP say the collision took place yesterday afternoon around 5:00 when a westbound Ford F-150 crossed into the eastbound lane and ran into a 2007 Pontiac G-6.
The driver of the Pontiac, a 32 year old man from Thunder Bay was killed and his two year old daughter was taken by air ambulence to Winnipeg for treatment of her injuries.
A 69 year old man who was driving the pick-up and his 17 year old passenger from Hawkstone, Ontario were taken by ambulence to hospital in Dryden.
The Trans-Canada was closed about 10 kilometers east of Ignace for about seven hours while the OPP conducted their investigation and the wreckage was removed from the highway.