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The accident took place yesterday morning near Inglis Lake closed the Trans-Canada Highway down for more than three hours.
The OPP say a westbound semi swerved into the eastbound lane to avoid a collision with another westbound transport.
Police say the tractor trailor unit ended up colliding with a couple of passenger vehicles in the eastbound lane and before crashing into traffic in the westbound lane.
A total of three people had to be transported to Lake of the Woods District hospital for treatment of minor injuries.