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OPP say the aircraft crashed just before 7:30 in the woods as it was approaching the Pickle Lake Airport.
Peter Hildebrand, a transportation safety official, says weather doesn't appear to have been a problem.
One survivor was airlifted to hospital in Winnipeg for treatment of minor injuries.
The names of the deceased won't be released until the family is notified.
Hildebrand says it was a private plane, a Laker LA-250 that went down.