A number of police agency's were involved in the bust including the Nishnawbe-Aski Police Service.
A total of nine search warrants were executed in the Greater Toronto Area, Mississauga, Kitchener-Waterloo and Thunder Bay as part of "Project Harrington".
In all, police laid 95 charges against 11-individuals, four of whom remain at large.
Police say the investigation targeted a network that transported and distributed large amounts of oxycodone and cocaine from southern Ontario to northwestern Ontario, including First Nations communities.
The quantity of the drugs seized is 1.3-million dollars.
Six of those charged are from Thunder Bay and one is from Weagamow First Nation.