The OPP's Organized Crime Enforcement Bureau along with the Kenora Joint Forces Drug Unit stopped the two men on Highway 71 last Friday.
Police say they had a quantity of crack cocaine, marijuana and a number of illegal prescription drugs in their possession.
Chesterfield Jordan of Winnipeg and Cameron Holder, a resident of Barbados have been charged with possession of a controlled substance.
They are due to appear in Kenora Court in October to face the charges.