The OPP says a tractor-trailor unit sustained extensive damage after catching fire while driving between Kenora and Vermillion Bay.
The incident took place last Thursday about 20 kilometers west of Vermillion Bay.
Police say when officers and personnel from the Machin Volunteer Fire Department showed up at the scene, the cab was completely engulfed in flames.
The trailor itself sustained only minimal damage.
No-one was injured and foul play is not suspected in the incident.
The OPP say the Trans-Canada was closed for about an hour while fire fighters worked to extinguish the blaze.