The first collision took place shortly after midnight on Highway 17 east of Kenora.
Police say a vehicle hit a rock cut about 10 kilometers east of the Highway 71 junction.
One man was killed in that collision.
The highway was closed overnight, but traffic is moving normally again in that area.
Meanwhile, one person is also dead in an accident that took place on Highway 71 in Sioux Narrows.
The OPP say they were called out around 6:30 this morning.